Alumni

Ph.D. Theses completed in the Lab

A.C. Papageorgiou, chemist. "Kinetic and crystallographic studies on glycogen phosphorylase: stereospecificity of the catalytic site." (1987-1991), Department of Biology, University of Athens, 1992.

D.D. Leonidas, chemist. "Solution and crystallographic studies on the activated glycogen phosphorylase." (1988-1992), Department of Biology, University of Athens, 1993.

S.E. Zographos, chemist. "Crystallographic studies on the R-state conformations of glycogen phosphorylase. Structural and catalytic role of the coenzyme pyridoxal 5'-phosphate. Mechanism of activation" (1993-1998), Department of Chemistry, University of Athens, 2000.

K.E. Tsitsanou, chemist. "Glycogen phosphorylase inhibitors as potential antidiabetic drugs" (1995-2001), Department of Biology, University of Athens, 2002.

V.T. Skamnaki, biochemist. "Structure/function relationship of phosphorylase kinase: kinetic and crystallographic studies" (1995-2001), Department of Biology, University of Athens, 2002.

M.N. Kosmopoulou, biochemist. "Glycogen phosphorylase as a molecular target for the development of new hypoglycaemic drugs" (2002-2005). Department of Chemistry, University of Ioannina, 2005

M.Sc. Theses completed in the Lab

Mr. Theodoros Hatjilois, Chemist. "Control of glycogen phosphorylase", Department of Chemistry, University of Athens (2003-2005)
Ms. Elena Anastasi, Chemist, "Cloning Expression and Purification of two mutant forms of human pancreatic glucokinase: kinetic and structural studies" Department of Chemistry, University of Athens (2004-2006)

Mr. Dimitrios N. Papageorgiou, Chemist, "Study of macromolecular targets involved in glycogen and RNA metabolism. Investigation of the inhibition mechanism of glycogen phosphorylase kinase (PhK) and the catalytic function human coilin interacting nuclear ATPase protein (hCINAP). Expression, purification, biochemical and structural studies in vitro and in silico" Department of Chemistry, University of Athens (2006-2008)

Ms. Chrysoula E. Kyritsi, Chemist, "Structure activity relationships of new glycogen phosphorylase inhibitors, analogues of N-(β-D-glucopyranosyl)-N΄-oxamides; kinetic and crystallographic evaluation" Department of Chemistry, University of Athens (2006-2008)

Ms. Christina Spanou, Biologist, "The binding of 5-diphosphoguanosine to eosinophil derived neurotoxin. Kinetic and crystallographic studies", Department of Biochemistry and Biotechnology, University of Thessaly (2009).

Ms. Christina Drakou, Chemist. "Kinetic and crystallographic studies on adenylate kinase 6" . Department of Chemistry, University of Athens (2010)

Final year student projects completed in the Lab

H.S. Tsitoura, biologist. "a-D- and b-D-glucose analogue inhibitors of glycogen phosphorylase. Kinetic and crystallographic studies" Department of Biology, University of Athens (1990-1991).

N. Katerelos, chemical engineer. "Crystallization and preliminary crystallographic characterization of pig skeletal muscle glycogen phosphorylase." Department of Chemical Engineering, National Technical University of Athens (1992-1993).

G. Koutsagelou, chemical engineer. "Crystallographic studies of enzyme macromolecules" Department of Chemical Engineering, National Technical University of Athens (1993-1994).

X. Charouli, biologist. "Kinetic analysis of a new class of derivatives of a-D-glucose, as inhibitors of glycogen phosphorylase". Department of Biology, University of Athens (1993-1994).

I. Manoussis. "The pH-dependence of catalytic activity of glycogen phosphorylase" Department of Biology, University of Athens (1994-1995).

E.D. Chrysina, chemical engineer. "Structure-assisted design of glycogen phosphorylase inhibitors", Department of Chemical Engineering, National Technical University of Athens (1995-1996).

A. Macrodemetris, chemical engineer. "Molecular recognition of 2-deoxy-Glc-6-P by glycogen phosphorylase b. Comparison with recoginition of the natural inhibitor Glc-6-P ", Department of Chemical Engineering, National Technical University of Athens (1995-1996).

L. Fragos-Livanios, chemical engineer. "Catalytic mechanism of glycogen phosphorylase: Binding site of anion activation. Binding of phosphite, phosphate and fluorophosphate anions", Department of Chemical Engineering, National Technical University of Athens (1995-1996).

D.D. Koutra, biologist. "Derivatives of a-D-glucose as potential antidiabetic drugs" Department of Biology, University of Athens (1996-1997).

E. Gika & C. Kravariti, chemists. "Isolation, purification, kinetic and crystallographic characterisation of PhKgtrnc. Catalytic mechanism of phosphorylase kinase", Department of Chemistry, University of Athens (1997-1998).

S. Avlonitis & D. Katharios, chemists. "Catalytic mechanism of glycogen phosphorylase: study of the ternary transition-state analogue with kinetic and crystallographic methods", Department of Chemistry, University of Athens (1997-1998).

X. Nikolakopoulos, chemical engineer. "Kinetic and crystallographic studies of glucopyranose hydantoin analogues inhibitors of glycogen phosphorylase", Department of Chemical Engineering, National Technical University of Athens (1998-1999).

N. Gavalas, biochemist. "Kinetic and structural characterisation of a new allosteric site of glycogen phosphorylase b", University of Sheffield (1999-2000).

A. Thanasoulas, chemical engineer. "Kinetic and crystallographic studies on flavopiridol binding to glycogen phosphorylase", Department of Chemical Engineering, National Technical University of Athens (1999-2000).

N. Panagiotopoulos, molecular biologist. "Kinetic and crystallographic studies of indirubin and indirubin analogues as inhibitors of glycogen phosphorylase", University of Liverpool, UK (1999-2000).

E. Anagnostou, chemical engineer. "Kinetic and crystallographic study of two bioisosteric inhbitors of glycogen phosphorylase b", Department of Chemical Engineering, National Technical University of Athens(2001-2002).

K. Tiraidis & I. Loupasakis-Loupasis, chemists. "Kinetic and crystallographic research of p-Nitro-N-benzoyl-N'-beta-D-glucopyranosyl urea as glycogen phosphorylase's inhibitor", Department of Chemistry, University of Athens (2001-2002).

G.N. Hatzopoulos, molecular biologist. "Kinetic and crystallographic analysis of inhibitor of ribonucleases", Department of Molecular Biology and Genetics, Democritus University of Thrace (2004).

S.P. Chatziioanou, chemical engineer. "Kinetic and crystallographic research of 2-(3-chlorophenyl)-8-(1,2,3,4- tetrahydro-1-methylpyridin-4-yl)-5,7-dihydroxy-4H-chromen-4-one (flavo5) as glycogen phosphorylase's inhibitor", Department of Chemical Engineering, National Technical University of Athens(2005).

A. Karampetsou, Molecular Biologist-Genetist. "Cloning, overexpression, isolation and purification of human recombinant proteins." Department of Molecular Biology and Genetics, Democritus University of Thrace (2006).

M. Daskalaki, Molecular Biologist-Genetist. "Design of glucose analogues, inhibitors of glycogen phophorylase as potential hypoglycaemic drugs. Kinetic and crystallographic studies." Department of Molecular Biology and Genetics, Democritus University of Thrace (2007).

I. Bosmi, Molecular Biologist-Genetist. "The new allosteric site of glycogen phosphorylase as a target for structure driven design of new galactose based hypoglycaemic drugs." Department of Molecular Biology and Genetics, Democritus University of Thrace (2007).

V. Kouneli, Molecular Biologist-Genetist. "Kinetic and crystalographic analysis of the binding of uridine 3' phosphate to Ribonuclease A" Department of Molecular Biology and Genetics, Democritus University of Thrace (2008).

V. Tsirkone, Biochemist. "Structural and kinetic studies on the binding of uridine 5' phosphate and uridine 5' diphosphate to Ribonuclease A." Department of Biochemistry and Biotechnology, University of Thessaly (2008).

G. Kizilis, Chemical engineer, "Kinetic and structural studies of glycogen phosphorylase inhibitors as potential hypoglycaemic agents." Department of Chemical Engineering, National Technical University of Athens (2008).

M. Antoniou, Molecular Biologist-Genetist. "Kinetic and crystalographic analysis of the binding of 5' diphosphate adenosine to Ribonuclease A", Department of Molecular Biology and Genetics, Democritus University of Thrace (2010).

Research Interests:

Control of glycogen metabolism

Phosphoenolpyruvate carboxykinase

Pancreatic glucokinase

Ribonucleases

Carbohydrate recognition
Human TAFs9 proteins
Xylanases and feruloyl esterases

Olfactory Binding Proteins

In the News:

EUROSTRUCT: European consolidation and promotion of research capacity in the area of structure-based drug discovery

ENAROMaTIC: European Network for Advanced Research on Olfaction for Malaria Transmitting Insect Control

EURODESY: A European Early Stage Research Training Site for Design and Synthesis