Institute of Organic and Pharmaceutical Chemistry

The National Hellenic Research Foundation

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STRUCTURAL BIOLOGY AND CHEMISTRY SYMPOSIUM

Dedicated to memory of Dr. Nikos G. Oikonomakos

Athens, 30 – 31 October 2009

Program

STRUCTURAL BIOLOGY AND CHEMISTRY SYMPOSIUM

Friday 30th October

09:00 - 09:30

Welcome

Chair Persons: E. Eliopoulos - S.E. Zographos

09:30 - 10:00

Prof. K.R. Acharya: Structural Molecular Biology Research at Bath – Contribution by Nikos Oikonomakos through Athens - Bath link

10:00 - 10:30

Prof. A. MacKerell: Optimizing ligand-protein interactions via SILCS: Site Identification by Ligand Competitive Saturation

10:30 - 11:00

Prof. D.I. Stuart: The role of technologies in helping understand virus structure and evolution

11:00 - 11:30

Prof. L. Somsák: Approaching the nanomolar range with glucose analogue inhibitors of glycogen phosphorylase: N-acyl-N’-β-D-glucopyranosyl ureas and beyond

12:00 - 15:00

Lunch break and INSTRUCT meeting

Chair Persons: I.M. Mavridis - A. Tsitsanou

15:00 - 15:30

Prof. A. Gimisis: Exploring the Catalytic Site of Glycogen Phosphorylase with β-D-Glucopyranosyl-Nucleoside Inhibitors

15:30 - 16:00

Prof. L. Agius: Physiological control of liver glycogen phosphorylase by substrate and endocrine mechanisms:  the value of pharmacological tools

16:00 - 16:30

Prof. P. T.W .Cohen: The phosphorylase α interaction with the hepatic glycogen targeting subunit of protein phosphatase 1 as an anti-diabetic target

16:30 - 17:00

Prof. G. Fleet: Rare and new monosaccharides: a bit of chemistry and a lot of biotechnology

17:00 - 17:30

 Coffee break

Chair Persons: S. Hamodrakas -  V. Skamnaki

17:30 - 18:00

Prof. L.N. Johnson: The structural basis for control by phosphorylation

18:00 - 18:30

Prof. S.J. Tzartos: Current knowledge on the structure of nicotinic acetylcholine receptors and our own efforts

18:30 - 19:00

Dr. I.Μ. Mavridis: High resolution structures of several 2[4Fe-4S] ferredoxins explain the reduction potential of [4Fe-4S] clusters

19:00 - 20:00

Dr. A.C. Papageorgiou: Understanding proteins: A journey through structural biology and chemistry

20:30 - 23:00

Dinner

 

Saturday 31st October

Chair Persons: A. Hountas- J.M. Hayes

10:00 - 10:30

Prof. A. Giannis: From Homer to Hedgehog: Synthesis of Cyclopamine Using a Biomimetic and Diastereoselective Approach

10:30 - 11:00

Prof. E. Eliopoulos: Odorant Binding Proteins. The mosquito olfaction target

11:00 - 11:30

Prof. M. Wilmanns: Catalytic promiscuity in M. tuberculosis

11:30 - 12:00

Prof. J.P. Praly: Glycochemistry, glycomimics, and amino acids in the context of diabetes

12:00 - 12:30

Closing remarks

* Please confirm your participation to the Dinner to Ms. Fotini Kalatzi

 
 
  The symposium is funded by the FP7 Capacities Program EUROSTRUCT