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Structure/function relationship in recombinant human TAFs9 proteins
The central aim of this project is to achieve the structural and functional characterisation of the human proteins TAFII31 and hCIP1, that are encoded as alternatively spliced transcripts of the TAF9 genomic locus. Elucidating the biological function of these proteins is of great interest, as they may be key molecules linking the basal transcription machinery and aspects of pre-mRNA metabolism, and because of their possible involvement in neurodegenerative pathways (In collaboration with Prof. Niovi Santama, Dept. of Biological Sciences, University of Cyprus).
Funding
General Secretariat for Research and Technology (GSRT)
"Structure-function relationship of TAF9 proteins" ENTER 2001, code: 01ER 115, 2003, (2004-2006). Budget: 65.588 €.
EU-FP6
Human Resources and Mobility activity, Marie Curie European Reintegration Grant "Structure-function relationship of TAF9 proteins" MERGE-CT-2004-006358, (2004-2005). Budget: 40.000 €.
Cyprus Research Promotion Foundation
"Protein complexes of CINAP: composite molecular targets for the understanding of human disease" Thematic Research Grant YGEIA 0506/05 (2007-2009). Total budget: 152.850 €, Budget for NHRF: 16.879 €.
Research Interests:
Control of glycogen metabolism
Phosphoenolpyruvate carboxykinase
Carbohydrate
recognition
Human TAFs9 proteins
Xylanases and feruloyl esterases